Chemistry and chemical engineering

Chemistry investigates the composition, structure, properties, and behavior of matter at the molecular and atomic level, while chemical engineering applies this knowledge to design processes and materials for practical use. The field bridges fundamental science with technological applications, from understanding how atoms bond to developing new drugs, materials, and energy systems.

Key challenges include designing molecules and materials with precisely controlled properties, developing sustainable chemical processes, and creating artificial systems that can perform complex chemistry with the precision of biological systems. Modern chemistry increasingly relies on computational modeling and automation to accelerate discovery and synthesis.

The 10 chemistry and chemical engineering problems

* These are just preliminary ideas and do not represent final problems of the Berkeley 100 Challenge. The final problems will be determined by our Scientific Committees.

  • Scalable Artificial Photosynthesis

  • Room-Temperature Superconductor Synthesis

  • Targeted Protein Degradation Platform

  • Carbon Dioxide to Value Catalysis

  • Universal Chemical Synthesis Machine

  • Dynamic Adaptive Materials

  • Complete Enzymatic Pathway Design

  • Quantum Chemistry at Biological Scale

  • Programmable Chemical Assembly

  • Chemical Nervous System

Chemistry and chemical engineering problem sample

* These are just preliminary ideas and do not represent final problems of the Berkeley 100 Challenge. The final problems will be determined by our Scientific Committees.

Room-Temperature Superconductor Synthesis

Problem Statement:

Synthesize and characterize a chemical compound that exhibits superconductivity at room temperature (≥298K) and ambient pressure, with critical current density sufficient for practical applications.

Evaluation Criteria:

  • Verified superconductivity at ≥298K and atmospheric pressure

  • Critical current density exceeding 105 A/cm2

  • Complete structural and compositional characterization

  • Reproducible synthesis protocol

  • Stability in atmospheric conditions for at least 1 year

  • Theoretical explanation of the superconducting mechanism

Feasibility Assessment: 

Extremely challenging, likely requiring 15-25 years. Requires revolutionary advances in materials design and synthesis. Progress in understanding high-temperature superconducting mechanisms, computational prediction of novel materials, and high-throughput synthesis and characterization methods would be important precursors.

Impact on the Field: 

Would revolutionize materials science and enable transformative technologies in energy transmission, transportation, and computing. Would likely reveal new fundamental understanding of electron pairing mechanisms. May establish new paradigms for designed quantum materials with implications for other quantum phenomena.

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